“The trash doesn't get taken out until the insulin gets lower... most people have been making buckets of insulin without knowing it.” — Dr. Annette Bosworth (Dr. Boz)
If you’ve ever felt like your brain is "sluggish" or full of static, you might not be tired. You might be toxic.
Dr. Annette Bosworth (Dr. Boz) frames brain health through a powerful metaphor: "Taking out the trash." Every day, your brain cells create metabolic waste. In a healthy brain, a process called autophagy (literally "self-eating") sweeps this trash away.
But there is a gatekeeper to this process: Insulin.
When insulin is high—which happens chronically in a diet high in processed carbs—it signals "growth" and "storage." It effectively locks the doors to the trash room. The waste accumulates. Over years, this "trash" manifests first as brain fog and anxiety, and eventually as the neurodegeneration seen in Alzheimer’s (often called Type 3 Diabetes) and Parkinson’s.
The solution isn't just "eating better." It's switching fuel systems entirely to perform a deep clean.
1. The Metric: The "Dr. Boz Ratio" (GKI)
A standard glucose test is insufficient; it only tells you half the story. You can have "normal" blood sugar but be pumping out massive amounts of insulin to keep it there.
To see the truth, Dr. Boz uses the , a metric originally developed by cancer researchers to track metabolic health. It measures the relationship between your fuel (glucose) and your repair signal (ketones).



